Interactions Between Angiotensin-(1-7), Kinins, and Angiotensin II in Kidney and Blood Vessels
نویسندگان
چکیده
منابع مشابه
Interactions between angiotensin-(1-7), kinins, and angiotensin II in kidney and blood vessels.
The heptapeptide angiotensin (Ang)-(1-7) is currently considered one of the biologically active end products of the renin-angiotensin system. The formation of Ang-(1-7) by pathways independent of Ang II generation, the selectivity of its actions, and its peculiar property of exhibiting effects that are partially opposite of those of the parent compound, Ang II, confer a unique biochemical and f...
متن کاملImbalance between angiotensin II and angiotensin-(1–7) in human coronary atherosclerosis
OBJECTIVE Our previous studies found that angiotensin-(1-7) (Ang-(1-7)) is an endogenous counter-factor of angiotensin II (Ang-II). However, the balance between Ang-II and Ang-(1-7) in the development of human coronary atherosclerosis is not determined. METHODS AND RESULTS The plasma levels of Ang-II and Ang-(1-7) were detected by enzyme-linked immunosorbent assay (ELISA) in 112 patients with...
متن کاملEffects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.
Angiotensin-converting enzyme inhibitors (ACEi) improve cardiac function and remodeling and prolong survival in patients with heart failure (HF). Blockade of the renin-angiotensin system (RAS) with an angiotensin II type 1 receptor antagonist (AT1-ant) may have a similar beneficial effect. In addition to inhibition of the RAS, ACEi may also act by inhibiting kinin destruction, whereas AT1-ant m...
متن کاملAngiotensin-(1-7) and Its Effects in the Kidney
Angiotensin-(1-7) (Ang-[1-7]) is a heptapeptide member of the renin-angiotensin system (RAS), and acts as a vasodilator and antagonist of angiotensin II (Ang II) in the vasculature. The role of Ang-(1-7) in regulating kidney function is not well understood. Within the kidneys, Ang-(1-7) is generated by angiotensin-converting enzyme 2 (ACE2)-mediated degradation of Ang II, sequential cleavage of...
متن کاملInteraction between Angiotensin Ii, Hypertension and Inflammation in Rat Kidney
INTERACTIONS BETWEEN ANGIOTENSIN II, HYPERTENSION AND INFLAMMATION IN RAT KIDNEY (Abstract): The renin-angiotensin system is one of the most important regulatory mechanisms of blood pressure homeostasis. Hypertension, a risk factor for chronic kidney disease, is able to induce renal injury by promoting inflammation. Inflammatory cytokines can induce fibrosis in various organs, including the kid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.38.3.660